It seems like itll start right after Summer Salt. If you havent read it yet I wont say much specifics but that means protagonist realized his true feelings and confessed to Misao. The truth is that he never "really loved" Touko even if getting cucked hurt him a lot. Thats why Summer Salt is just a long prologue, like Komarisou but even more so. The thing that is most interesting is that the story spans multiple years. I dont expect something as crazy as Gatenkei but Venus games always have long setup (this one has an entire game already lol) and developer nao is posting both JK and adult Misao art for the game everywhere. In the ci-en post showing the cast everyone has their younger forms (
https://ci-en.dlsite.com/creator/220/article/227814) and in the game site you can see a new tachi-e for JK Misao with her older version in the background (
http://venus66.sakura.ne.jp/sin20top.html). Hes posted more new versions of her tachi-e for both ages on ci-en too.
From the secret epilogue we know that at least 2 years are going to pass, maybe more. I dont think shes going to get stolen immediately because the subtitle "virgin man and virgin woman married couple" sounds like theyll be awkward in bed together for a while lol. Other things:
-Adult Misao has both her weird pigtails and ponytail. Would be hot if thats something the netori man suggested since Venus doesnt use that trick often.
-BTW nao actually replied vaguely to people who asked what is Ayas role (heroine from the comic he released years ago). Shes a student at the school protagonist goes to work.
-nao touched up a bit the tachi-e of Misaos mother since he first show it to make her cuter. Maybe netori man will make her fall first to get Misao?
-Supernatural element is going to get focus since the site thumbnail has the creepy shrine. Lots of hints of that and the special pheromones/blood of Anoyamas men and women and well finally know the truth.